Can Green Tea Alleviate Inflammatory Bowel Disease? – Medical Field

Green tea contains the active plant ingredient epigallocatechin-3-gallate (EGCG), which has significant anti-inflammatory properties and may also help relieve chronic inflammatory bowel disease.

Based on a systematic review of existing preclinical research, the Chinese research team investigated the effects of epigallocatechin-3-gallate against inflammatory bowel disease and identified possible underlying mechanisms. The results are published in the specialized journal “Phytomedicine”.

Health benefits of green tea

Green tea is said to have many positive health effects, from positive effects on gut flora to reduced risk of cardiovascular disease and even anti-cancer effects.

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One of the main active ingredients in green tea is EGCG, which is also believed to have significant anti-inflammatory properties and potential pharmacological effects in inflammatory bowel disease, the team explained.

However, the evidence for the use of EGCG in the treatment of chronic inflammatory bowel disease is still insufficient.

Effects of EGCG investigated

Based on a comprehensive evaluation of available preclinical studies, researchers have now attempted to assess the effects of green tea polyphenols. For this purpose, a meta-analysis of 19 animal studies was conducted.

Effects on inflammatory bowel disease pathology as well as indicators of inflammation and oxidative stress were focused on. In addition, the dose-response relationship was evaluated and an attempt was made to determine the optimal dosage for the treatment of inflammatory bowel disease.

Alleviation of the course of the disease

The results show that EGCG alleviates inflammatory bowel disease by reducing indicators of inflammation and oxidative stress, the research team reports.

Among other things, significant improvements in the so-called disease activity index, macroscopic colitis damage index and histological findings were observed. The researchers also observed a reduction in many important markers of inflammation and oxidative stress.

What is the optimal dose?

Oral administration of EGCG has shown superior efficacy compared to other administration methods, and according to the researchers, the results of a dose-response analysis showed that the optimal dosage range was 32 to 62 milligrams of EGCG per kilogram of body weight. : day – with the duration of intervention from 4.8 to 13.6 days.

In general, the active ingredient of green tea in the indicated dosages can have an extremely positive effect on chronic inflammatory bowel diseases, the research team concluded. (fp)

Author and source information

This text meets the requirements of the medical literature, medical guidelines and current studies and has been verified by medical professionals.

Sources:

  • Feng Wei, Delin Li, Xiaodong Chen, Yubing Li, Yuting Zeng, Yilin Cai, Youtao Zeng, Yu Chen, Xiao Ma, Jinhao Zeng. Therapeutic effects of epigallocatechin-3-gallate for inflammatory bowel disease. preclinical meta-analysis; Botany (veröffentlicht 02.02.2024), sciencedirect.com
  • Jing Zhao, Alan Blaney, Xiaorong Liu, Lauren Gandy, Weihua Jin et al. EGCG binds the intrinsically disordered N-terminal domain of p53 and disrupts the p53-MDM2 interaction Nature Communications (veröffentlicht 12.02.20)

Important NOTE:
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a doctor's visit.

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